XNAS 19 May, 2026 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Kristopher L. Hanson | General Counsel | Sale of securities on an exchange or to another person at price $ 27.61 per share. | 11 May 2026 | 284 | 175,964 | - | 27.6 | 7,841 | Voting Common Stock |
| Kristopher L. Hanson | General Counsel | Sale of securities on an exchange or to another person at price $ 30.56 per share. | 11 May 2026 | 5,808 | 162,331 | - | 30.6 | 177,492 | Voting Common Stock |
| Kristopher L. Hanson | General Counsel | Sale of securities on an exchange or to another person at price $ 30.04 per share. | 11 May 2026 | 6,979 | 168,139 | - | 30.0 | 209,649 | Voting Common Stock |
| Kristopher L. Hanson | General Counsel | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 11 May 2026 | 846 | 175,118 | - | 28.7 | 24,280 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.56 per share. | 07 May 2026 | 1,582 | 1,529,514 | - | 28.6 | 45,182 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 30.56 per share. | 07 May 2026 | 5,890 | 1,512,329 | - | 30.6 | 179,998 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 30.04 per share. | 07 May 2026 | 6,871 | 1,518,219 | - | 30.0 | 206,405 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 07 May 2026 | 877 | 1,525,090 | - | 28.7 | 25,170 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 27.57 per share. | 07 May 2026 | 342 | 1,525,967 | - | 27.6 | 9,429 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.20 per share. | 07 May 2026 | 3,205 | 1,526,309 | - | 29.2 | 93,586 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 27.48 per share. | 07 May 2026 | 29,624 | 1,531,096 | - | 27.5 | 814,068 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.15 per share. | 07 May 2026 | 5,220 | 1,560,720 | - | 29.2 | 152,163 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.47 per share. | 07 May 2026 | 14,880 | 1,565,940 | - | 28.5 | 423,634 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.28 per share. | 07 May 2026 | 721 | 242,729 | - | 28.3 | 20,390 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.10 per share. | 07 May 2026 | 117 | 346,059 | - | 29.1 | 3,405 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.52 per share. | 07 May 2026 | 4,321 | 346,176 | - | 28.5 | 123,235 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.13 per share. | 04 May 2026 | 15,603 | 1,580,820 | - | 29.1 | 454,515 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.04 per share. | 04 May 2026 | 8,098 | 1,596,423 | - | 28.0 | 227,068 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.00 per share. | 04 May 2026 | 928 | 1,604,521 | - | 29 | 26,912 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.12 per share. | 04 May 2026 | 9,544 | 1,605,449 | - | 28.1 | 268,377 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 30.08 per share. | 04 May 2026 | 697 | 1,614,993 | - | 30.1 | 20,966 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.56 per share. | 04 May 2026 | 311 | 1,615,690 | - | 29.6 | 9,193 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.37 per share. | 04 May 2026 | 5,427 | 1,616,001 | - | 28.4 | 153,964 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 27.50 per share. | 04 May 2026 | 9,136 | 1,621,428 | - | 27.5 | 251,240 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 27.50 per share. | 04 May 2026 | 9,250 | 285,907 | - | 27.5 | 254,375 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.37 per share. | 04 May 2026 | 5,526 | 280,381 | - | 28.4 | 156,773 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 29.13 per share. | 04 May 2026 | 16,421 | 243,450 | - | 29.1 | 478,344 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 29.56 per share. | 04 May 2026 | 320 | 280,061 | - | 29.6 | 9,459 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 30.08 per share. | 04 May 2026 | 705 | 279,356 | - | 30.1 | 21,206 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.12 per share. | 04 May 2026 | 10,132 | 269,224 | - | 28.1 | 284,912 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 29.00 per share. | 04 May 2026 | 963 | 268,261 | - | 29 | 27,927 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.04 per share. | 04 May 2026 | 8,390 | 259,871 | - | 28.0 | 235,256 | Voting Common Stock |
| Kristopher L. Hanson | General Counsel | Sale of securities on an exchange or to another person at price $ 28.29 per share. | 04 May 2026 | 3,908 | 177,227 | - | 28.3 | 110,557 | Voting Common Stock |
| Kristopher L. Hanson | General Counsel | Sale of securities on an exchange or to another person at price $ 30.08 per share. | 04 May 2026 | 683 | 176,248 | - | 30.1 | 20,545 | Voting Common Stock |
| Kristopher L. Hanson | General Counsel | Sale of securities on an exchange or to another person at price $ 29.56 per share. | 04 May 2026 | 296 | 176,931 | - | 29.6 | 8,750 | Voting Common Stock |
| Kristopher L. Hanson | General Counsel | Sale of securities on an exchange or to another person at price $ 27.50 per share. | 04 May 2026 | 9,030 | 181,135 | - | 27.5 | 248,325 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 29.07 per share. | 04 May 2026 | 2,068 | 356,256 | - | 29.1 | 60,117 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.36 per share. | 04 May 2026 | 4,803 | 387,824 | - | 27.4 | 131,410 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.28 per share. | 04 May 2026 | 8,989 | 378,835 | - | 28.3 | 254,209 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 29.56 per share. | 04 May 2026 | 325 | 378,510 | - | 29.6 | 9,607 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 30.12 per share. | 04 May 2026 | 787 | 377,723 | - | 30.1 | 23,704 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.12 per share. | 04 May 2026 | 9,935 | 367,788 | - | 28.1 | 279,372 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 29.00 per share. | 04 May 2026 | 968 | 366,820 | - | 29 | 28,072 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.04 per share. | 04 May 2026 | 8,496 | 358,324 | - | 28.0 | 238,228 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 27.50 per share. | 04 May 2026 | 9,180 | 391,597 | - | 27.5 | 252,450 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.13 per share. | 04 May 2026 | 15,900 | 350,497 | - | 29.1 | 463,167 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.04 per share. | 04 May 2026 | 8,152 | 366,397 | - | 28.0 | 228,582 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.00 per share. | 04 May 2026 | 931 | 374,549 | - | 29 | 26,999 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.12 per share. | 04 May 2026 | 9,645 | 375,480 | - | 28.1 | 271,217 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.08 per share. | 04 May 2026 | 700 | 385,125 | - | 30.1 | 21,056 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.56 per share. | 04 May 2026 | 312 | 385,825 | - | 29.6 | 9,223 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.37 per share. | 04 May 2026 | 5,460 | 386,137 | - | 28.4 | 154,900 | Voting Common Stock |
| Jonathan Gillis | CAAO and PAO | Sale of securities on an exchange or to another person at price $ 28.94 per share. | 27 Apr 2026 | 7,914 | 243,140 | - | 28.9 | 229,031 | Voting Common Stock |
| Jonathan Gillis | CAAO and PAO | Sale of securities on an exchange or to another person at price $ 30.83 per share. | 27 Apr 2026 | 700 | 181,219 | - | 30.8 | 21,581 | Voting Common Stock |
| Jonathan Gillis | CAAO and PAO | Sale of securities on an exchange or to another person at price $ 30.33 per share. | 27 Apr 2026 | 17,235 | 181,919 | - | 30.3 | 522,738 | Voting Common Stock |
| Jonathan Gillis | CAAO and PAO | Sale of securities on an exchange or to another person at price $ 30.46 per share. | 27 Apr 2026 | 14,363 | 199,154 | - | 30.5 | 437,497 | Voting Common Stock |
| Jonathan Gillis | CAAO and PAO | Sale of securities on an exchange or to another person at price $ 29.60 per share. | 27 Apr 2026 | 29,623 | 213,517 | - | 29.6 | 876,841 | Voting Common Stock |
| Anatol Kreitzer | Chief Discovery Officer | Sale of securities on an exchange or to another person at price $ 28.96 per share. | 27 Apr 2026 | 8,346 | 248,266 | - | 29.0 | 241,700 | Voting Common Stock |
| Anatol Kreitzer | Chief Discovery Officer | Sale of securities on an exchange or to another person at price $ 30.50 per share. | 27 Apr 2026 | 7,821 | 211,190 | - | 30.5 | 238,541 | Voting Common Stock |
| Anatol Kreitzer | Chief Discovery Officer | Sale of securities on an exchange or to another person at price $ 29.63 per share. | 27 Apr 2026 | 29,255 | 219,011 | - | 29.6 | 866,826 | Voting Common Stock |
| Jonathan Gillis | CAAO and PAO | Sale of securities on an exchange or to another person at price $ 26.61 per share. | 15 Apr 2026 | 3,590 | 251,054 | - | 26.6 | 95,530 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 27.49 per share. | 15 Apr 2026 | 7,575 | 1,630,564 | - | 27.5 | 208,237 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 27.01 per share. | 15 Apr 2026 | 2,477 | 1,638,139 | - | 27.0 | 66,904 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 26.93 per share. | 15 Apr 2026 | 9,135 | 1,640,616 | - | 26.9 | 246,006 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 26.82 per share. | 15 Apr 2026 | 1,730 | 297,940 | - | 26.8 | 46,399 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 27.01 per share. | 15 Apr 2026 | 686 | 297,254 | - | 27.0 | 18,529 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 27.49 per share. | 15 Apr 2026 | 2,097 | 295,157 | - | 27.5 | 57,647 | Voting Common Stock |
| Kristopher L. Hanson | General Counsel | Sale of securities on an exchange or to another person at price $ 27.01 per share. | 15 Apr 2026 | 73 | 190,390 | - | 27.0 | 1,972 | Voting Common Stock |
| Kristopher L. Hanson | General Counsel | Sale of securities on an exchange or to another person at price $ 27.49 per share. | 15 Apr 2026 | 225 | 190,165 | - | 27.5 | 6,185 | Voting Common Stock |
| Kristopher L. Hanson | General Counsel | Sale of securities on an exchange or to another person at price $ 26.80 per share. | 15 Apr 2026 | 1,529 | 190,463 | - | 26.8 | 40,977 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.00 per share. | 15 Apr 2026 | 29 | 392,714 | - | 27 | 783 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.49 per share. | 15 Apr 2026 | 87 | 392,627 | - | 27.5 | 2,392 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 26.87 per share. | 15 Apr 2026 | 2,806 | 392,743 | - | 26.9 | 75,397 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 27.49 per share. | 15 Apr 2026 | 881 | 400,777 | - | 27.5 | 24,219 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 27.01 per share. | 15 Apr 2026 | 288 | 401,658 | - | 27.0 | 7,779 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 26.84 per share. | 15 Apr 2026 | 2,044 | 401,946 | - | 26.8 | 54,861 | Voting Common Stock |
| Anatol Kreitzer | Chief Discovery Officer | Sale of securities on an exchange or to another person at price $ 26.61 per share. | 15 Apr 2026 | 3,316 | 256,612 | - | 26.6 | 88,239 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 26.90 per share. | 15 Apr 2026 | 8,593 | 316,466 | - | 26.9 | 231,152 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 18.03 per share. | 20 Feb 2026 | 2,195 | 337,059 | - | 18.0 | 39,576 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 20 Feb 2026 | 736 | 325,059 | - | 18.1 | 13,358 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 19.06 per share. | 20 Feb 2026 | 476 | 325,795 | - | 19.1 | 9,073 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 18.39 per share. | 20 Feb 2026 | 10,788 | 326,271 | - | 18.4 | 198,391 | Voting Common Stock |
| George Pavlov | Director | Purchase of securities on an exchange or from another person at price $ 17.86 per share. | 18 Feb 2026 | 9,920 | 25,000 | - | 17.9 | 177,171 | Voting Common Stock |
| George Pavlov | Director | Purchase of securities on an exchange or from another person at price $ 17.57 per share. | 18 Feb 2026 | 4,422 | 15,080 | - | 17.6 | 77,695 | Voting Common Stock |
| George Pavlov | Director | Purchase of securities on an exchange or from another person at price $ 17.48 per share. | 18 Feb 2026 | 10,658 | 10,658 | - | 17.5 | 186,302 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 18.21 per share. | 13 Feb 2026 | 12,116 | 339,254 | - | 18.2 | 220,632 | Voting Common Stock |
| Timothy John Garnett | Director | Purchase of securities on an exchange or from another person at price $ 17.89 per share. | 10 Feb 2026 | 14,124 | 14,124 | - | 17.9 | 252,678 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 10 Feb 2026 | 241 | 351,370 | - | 18 | 4,338 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 18.12 per share. | 10 Feb 2026 | 6,622 | 351,611 | - | 18.1 | 119,991 | Voting Common Stock |
| Jonathan Gillis | CAAO and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 6,020 | 254,523 | - | 0 | Voting Common Stock | |
| Jonathan Gillis | CAAO and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 24,455 | 24,455 | - | - | Employee Stock Option (right to buy) | |
| Christopher A. Kroeger | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 93,955 | 93,955 | - | - | Employee Stock Option (right to buy) | |
| Christopher A. Kroeger | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 23,145 | 1,649,751 | - | 0 | Voting Common Stock | |
| James Lillie | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 7,730 | 298,862 | - | 0 | Voting Common Stock | |
| James Lillie | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 31,395 | 31,395 | - | - | Employee Stock Option (right to buy) | |
| Kristopher L. Hanson | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 7,730 | 191,582 | - | 0 | Voting Common Stock | |
| Kristopher L. Hanson | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 31,395 | 31,395 | - | - | Employee Stock Option (right to buy) | |
| Vishwas Setia | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 7,730 | 395,549 | - | 0 | Voting Common Stock | |
| Vishwas Setia | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 31,395 | 31,395 | - | - | Employee Stock Option (right to buy) | |
| Erin Pennock Foff | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 13,360 | 403,835 | - | 0 | Voting Common Stock | |
| Erin Pennock Foff | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 54,240 | 54,240 | - | - | Employee Stock Option (right to buy) | |
| Anatol Kreitzer | Chief Discovery Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 24,455 | 24,455 | - | - | Employee Stock Option (right to buy) | |
| Anatol Kreitzer | Chief Discovery Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2026 | 6,020 | 259,928 | - | 0 | Voting Common Stock | |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 18.02 per share. | 02 Feb 2026 | 7,039 | 358,234 | - | 18.0 | 126,843 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 02 Feb 2026 | 1 | 358,233 | - | 18 | 18 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 18.61 per share. | 28 Jan 2026 | 5,860 | 393,811 | - | 18.6 | 109,055 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 18.11 per share. | 28 Jan 2026 | 6,612 | 365,273 | - | 18.1 | 119,743 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 18.55 per share. | 28 Jan 2026 | 21,262 | 371,885 | - | 18.5 | 394,410 | Voting Common Stock |
| Robert C. Malenka | Director | Sale of securities on an exchange or to another person at price $ 19.05 per share. | 28 Jan 2026 | 664 | 393,147 | - | 19.0 | 12,649 | Voting Common Stock |
| Jonathan Gillis | CAAO and PAO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.98 per share. | 27 Jan 2026 | 22,050 | 248,503 | - | 18.0 | 396,459 | Voting Common Stock |
| Christopher A. Kroeger | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.98 per share. | 27 Jan 2026 | 204,146 | 1,626,606 | - | 18.0 | 3,670,545 | Voting Common Stock |
| James Lillie | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.98 per share. | 27 Jan 2026 | 45,055 | 291,132 | - | 18.0 | 810,089 | Voting Common Stock |
| Kristopher L. Hanson | General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.98 per share. | 27 Jan 2026 | 26,007 | 183,852 | - | 18.0 | 467,606 | Voting Common Stock |
| Vishwas Setia | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.98 per share. | 27 Jan 2026 | 33,382 | 387,819 | - | 18.0 | 600,208 | Voting Common Stock |
| Erin Pennock Foff | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.98 per share. | 27 Jan 2026 | 44,616 | 390,475 | - | 18.0 | 802,196 | Voting Common Stock |
| Anatol Kreitzer | Chief Discovery Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.98 per share. | 27 Jan 2026 | 42,099 | 253,908 | - | 18.0 | 756,940 | Voting Common Stock |
| Jonathan Gillis | CAAO and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 124,022 | 124,022 | - | - | Employee Stock Option (right to buy) | |
| Jonathan Gillis | CAAO and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 30,565 | 30,565 | - | 0 | Voting Common Stock | |
| Christopher A. Kroeger | Director, Chief Executive Officer | 27 Oct 2025 | 3,895 | 229,588 | - | - | Voting Common Stock | ||
| Christopher A. Kroeger | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 225,693 | 225,693 | - | 0 | Voting Common Stock | |
| Christopher A. Kroeger | Director, Chief Executive Officer | 27 Oct 2025 | 65,477 | 0 | - | - | Series C Preferred Stock | ||
| Christopher A. Kroeger | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 916,164 | 916,164 | - | - | Employee Stock Option (right to buy) | |
| James Lillie | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 132,023 | 132,023 | - | - | Employee Stock Option (right to buy) | |
| James Lillie | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 32,539 | 32,539 | - | 0 | Voting Common Stock | |
| Kristopher L. Hanson | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 27,098 | 27,098 | - | 0 | Voting Common Stock | |
| Kristopher L. Hanson | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 110,046 | 110,046 | - | - | Employee Stock Option (right to buy) | |
| Maria C. Walker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 6,294 | 6,294 | - | 0 | Voting Common Stock | |
| Maria C. Walker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 25,604 | 25,604 | - | - | Employee Stock Option (right to buy) | |
| Timothy John Garnett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 25,604 | 25,604 | - | - | Employee Stock Option (right to buy) | |
| Timothy John Garnett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 6,294 | 6,294 | - | 0 | Voting Common Stock | |
| Vishwas Setia | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 43,367 | 43,367 | - | 0 | Voting Common Stock | |
| Vishwas Setia | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 176,031 | 176,031 | - | - | Employee Stock Option (right to buy) | |
| Erin Pennock Foff | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 196,035 | 196,035 | - | - | Employee Stock Option (right to buy) | |
| Erin Pennock Foff | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 48,275 | 48,275 | - | 0 | Voting Common Stock | |
| Anatol Kreitzer | Chief Discovery Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 146,052 | 146,052 | - | - | Employee Stock Option (right to buy) | |
| Anatol Kreitzer | Chief Discovery Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 35,953 | 35,953 | - | 0 | Voting Common Stock | |
| Robert C. Malenka | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 34,390 | 399,671 | - | 0 | Voting Common Stock | |
| Robert C. Malenka | Director | 27 Oct 2025 | 3,895 | 31,672 | - | - | Voting Common Stock | ||
| Robert C. Malenka | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Oct 2025 | 139,610 | 139,610 | - | - | Employee Stock Option (right to buy) | |
| Robert C. Malenka | Director | 27 Oct 2025 | 65,477 | 0 | - | - | Series C Preferred Stock |